Shigeo Ohno Selected Research

PKC-3 protein

11/2018	Atypical Protein Kinase C λ/ι Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma.
11/2016	Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C.
9/2014	Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component.
7/2013	aPKCλ/ι is a beneficial prognostic marker for pancreatic neoplasms.
2/2013	High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis.
8/2011	Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence.
9/2009	aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.

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Shigeo Ohno Research Topics

Disease

21	Neoplasms (Cancer) 07/2022 - 04/2003
7	Breast Neoplasms (Breast Cancer) 07/2022 - 06/2008
4	Carcinogenesis 01/2020 - 06/2005
3	Pancreatic Neoplasms (Pancreatic Cancer) 11/2016 - 07/2013
3	Stomach Neoplasms (Stomach Cancer) 10/2015 - 01/2010
2	Inflammation (Inflammations) 01/2019 - 03/2006
2	Scleroatonic muscular dystrophy 09/2013 - 09/2006
2	Prostatic Neoplasms (Prostate Cancer) 08/2011 - 09/2009
2	Cysts 10/2006 - 04/2006
2	Hypoxia (Hypoxemia) 06/2005 - 05/2003
1	Triple Negative Breast Neoplasms 12/2021
1	Squamous Cell Carcinoma of Head and Neck 11/2018
1	Liver Diseases (Liver Disease) 04/2015
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 04/2015
1	Sclerosing Cholangitis 04/2015
1	Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 09/2013
1	Cicatrix (Scar) 08/2013
1	Neuroblastoma 08/2011
1	Adenocarcinoma 01/2010
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2010
1	Renal Insufficiency (Renal Failure) 01/2009
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2009
1	Genomic Instability 03/2007
1	Muscular Dystrophies (Muscular Dystrophy) 09/2006
1	Carcinoma (Carcinomatosis) 03/2005
1	Infections 01/2005
1	Type 2 Diabetes Mellitus (MODY) 01/2005
1	Glucose Intolerance 01/2005
1	Blister (Bulla) 05/2004
1	Insulin Resistance 09/2003
1	Hepatocellular Carcinoma (Hepatoma) 07/2003
1	Leukemia 07/2003
1	Retinoblastoma (Glioblastoma, Retinal) 05/2003
1	Cardiomegaly (Heart Hypertrophy) 05/2003
1	Heart Failure 05/2003

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 07/2021 - 04/2003
7	PKC-3 proteinIBA 11/2018 - 09/2009
3	Small Interfering RNA (siRNA)IBA 07/2022 - 09/2006
3	Phenobarbital (Luminal)FDA Link 07/2022 - 01/2022
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2009
3	Protein Kinase CIBA 12/2021 - 05/2003
3	Messenger RNA (mRNA)IBA 07/2021 - 03/2007
3	Protein Isoforms (Isoforms)IBA 03/2005 - 05/2003
2	Aldehyde Dehydrogenase 1 FamilyIBA 07/2022 - 12/2021
2	SodiumIBA 07/2022 - 01/2022
2	Estrogen ReceptorsIBA 07/2022 - 01/2022
2	Phosphates (Orthophosphate)IBA 07/2022 - 01/2022
2	SymportersIBA 07/2022 - 01/2022
2	Trypan Blue FDA Link 12/2021 - 01/2020
2	3- (1,3- benzothiazol- 2- yl)- 4- (4- methoxyphenyl)but- 3- enoic acidIBA 12/2021 - 07/2021
2	Protein Kinases (Protein Kinase)IBA 07/2021 - 02/2013
2	Cadherins (E-Cadherin)IBA 09/2014 - 01/2010
2	Interleukin-6 (Interleukin 6)IBA 08/2011 - 09/2009
2	protein kinase C lambdaIBA 01/2010 - 06/2008
2	IntegrinsIBA 03/2006 - 05/2004
1	Dihydrotachysterol (AT 10)IBA 01/2022
1	Atrial Natriuretic Factor (ANF)IBA 12/2021
1	Gold Sodium Thiomalate (Sodium Aurothiomalate)IBA 07/2021
1	EnzymesIBA 07/2021
1	CaspasesIBA 01/2020
1	IsoenzymesIBA 11/2016
1	Nicotine FDA Link 11/2016
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 10/2015
1	AntioxidantsIBA 04/2015
1	VitaminsIBA 04/2015
1	CateninsIBA 09/2014
1	Collagen Type IV (Type IV Collagen)IBA 09/2014
1	Peptide Hydrolases (Proteases)FDA Link 09/2013
1	Collagen Type VIIBA 09/2013
1	Serine (L-Serine)FDA Link 09/2013
1	Adenosine Diphosphate (ADP)IBA 08/2013
1	LuciferasesIBA 08/2013
1	Indicators and Reagents (Reagents)IBA 01/2010
1	DystrophinIBA 01/2010
1	UtrophinIBA 01/2010
1	Hormones (Hormone)IBA 09/2009
1	matrigelIBA 10/2006
1	CollagenIBA 10/2006
1	Laminin (Merosin)IBA 10/2006
1	GelsIBA 10/2006
1	Caspase 3 (Caspase-3)IBA 10/2006
1	ElonginIBA 06/2005
1	Amino Acids FDA Link 06/2005
1	Glucose (Dextrose)FDA LinkGeneric 01/2005
1	ActininIBA 05/2004
1	Sterol Regulatory Element Binding Protein 1IBA 09/2003
1	ElementsIBA 09/2003
1	SterolsIBA 09/2003
1	Triglycerides (Triacylglycerol)IBA 09/2003
1	Insulin (Novolin)FDA Link 09/2003
1	LipidsIBA 09/2003
1	DiterpenesIBA 07/2003
1	mezereinIBA 07/2003
1	gnidimacrinIBA 07/2003
1	Retinoblastoma ProteinIBA 05/2003
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 05/2003

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 01/2022 - 08/2013
1	Radiotherapy 07/2022
1	Therapeutics 01/2022
1	Gastrectomy 01/2010